Cotto's only loss was against Margarito. His nose was broken in the second round. In Margarito's fight against Mosley, it was discovered he had an illegal substance under his hand wraps. With this being Cotto's first fight back, I believe he is on a mission to prove that he lost that fight by the reason of the illegal hand wraps and not that Margarito was a better fighter.

Cotto by late TKO.