Most poker cashiers won't even put one in a count out as they know what will happen.
On the poker cruises, cruise casinos stock a lot of $50's for some unknown reason.
They tell me the same thing when poker players are onboard.
When I change up small bills for large ones, I never allow them to give me $50's as I can not use them in the poker area.
That said, I will take all that anyone wants to "give" me!!!!