Cheerios: Named after an effeminate British expression of typical British feigned caring.
Notre Dame: Named after the Mother of our Lord and Savior AND after Irishmen THROWING OFF THE YOKE OF BRITISH OPPRESSION!!

Cheerios: Small, slow-moving dumb little circles made of oats
Notre Dame: ENORMOUS, QUICK GENTLEMEN WARRIOR PRINCES forged by FIRE!!

Cheerios: Made to be devoured
Notre Dame: Made to DEVOUR!!

Cheerios: Often part of a complete breakfast for children
Notre Dame: Often part of COMPLETE DOMINATION OF OPPONENTS!!

Cheerios: Typically served with carton of milk
Notre Dame: Typically served with a can of WHOOP @$$!!

Cheerios: Made, formed and crafted by General Mills
Notre Dame: Made, formed and crafted by the Genius Robot, Choo Choo Charlie Weis!!

Cheerios: Good source of ruffage
Notre Dame: Good source of ROUGHNESS!!

Cherrios: Best served with plenty of milk on hand
Notre Dame: Best played with PLASMA and PAINKILLER on hand!!

In sum, the differences between Notre Dame and Cheerios are vast and noteworthy.