Tommy, I work in Tunica and have taken this trip several times. From Biloxi go up Hwy. 49 to Jackson. At Jackson, get on I-20 West to Vicksburg. Casinos at Vicksburg are just off the interstate. If you want to go to Natchez, you will need to go south on Hwy 61. If you want to skip it, then just go north on Hwy. 61 and follow the river all the way up to Tunica, hitting the other casino on the way. When you get to Sam's Town, be sure and say hello to me. I'll be in the dice pit on day shift, off Wednesday & Thursday.