I generally agree with Steve Bedo's comments. If an inlay is off-center by 1/32", not a problem. If significantly off, by 1/4" or more (approx.), that noticeably detracts from its symmetry with just a glance, then it would be less desirable, IMO. Especially if the chip is pretty common. If it's rare, then rarity will be the primary contributor to value.

You'll see comments -- both ways -- about "well-centered" chips. Some collectors don't care, and even ridicule the idea, while it is important to others. It is possible to get too "fussy" about chip appearance. We're not coin collectors, where a 70-point grading scale is used to evaluate. In fact, the C&W point value process never caught on in the chip collecting hobby. (The slabbers tried to use in in their failed attempt at slabbing ... but that's another story.)

There is one other subtlety to notice about older chip inlays, particularly on the Christy & Jones H&C chips. They would often orient inlays in relation to inserts such that a 3-insert chip would place them at 12:00 / 4:00 / 8:00 on one side. Then turn the chip over and the inserts would be at 6:00 / 10:00 / 2:00. Here are examples (pics from the Chip Guide) --

On 4-insert chips, the inserts would be at 12:00 / 3:00 / 6:00 / 9:00. See the Carver House set for an example (pics from Chip Guide) --

Though there's some variability in insert/inlay placement in these chips, the pride of workmanship in these old C&J's (and some other older molds too), make them little works of art, IMO.