I had not heard the fact that Mark Twain was associated with Virginia City till I read this auction narrative. Here's a paragraph I Googled up on Samuel Clemens' life:

Clemens was born on November 30, 1835 in Florida, Missouri, of a Virginian family. He was brought up in Hannibal, Missouri. After his father's death in 1847, he was apprenticed to a printer and wrote for his brother's newspaper. He later worked as a licensed Mississippi river-boat pilot. The Civil War put an end to the steamboat traffic and Clemens moved to Virginia City, where he edited the Territorial Enterprise. On February 3, 1863, 'Mark Twain' was born when Clemens signed a humorous travel account with that pseudonym.